Two optimized combination assays to examine apoptosis pathways in clinical samples
نویسندگان
چکیده
منابع مشابه
Apoptosis: from Signalling Pathways to Therapeutic Tools
Apoptosis or programmed cell death is a gene regulated phenomenon which is important in both physiological and pathological conditions. It is characterized by distinct morphological features including chromatin condensation, cell and nuclear shrinkage, membrane blebbing and oligonucleosomal DNA fragmentation. Although, two major apoptotic pathways including 1) the death receptor (extrinsic) and...
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Apaf-1(-/-) or caspase-3(-/-) cells treated with a variety of apoptosis inducers manifest apoptosis-associated alterations including the translocation of apoptosis-inducing factor (AIF) from mitochondria to nuclei, large scale DNA fragmentation, and initial chromatin condensation (stage I). However, when compared with normal control cells, Apaf-1(-/-) or caspase-3(-/-) cells fail to exhibit oli...
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apoptosis or programmed cell death is a gene regulated phenomenon which is important in both physiological and pathological conditions. it is characterized by distinct morphological features including chromatin condensation, cell and nuclear shrinkage, membrane blebbing and oligonucleosomal dna fragmentation. although, two major apoptotic pathways including 1) the death receptor (extrinsic) and...
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ژورنال
عنوان ژورنال: Cytometry Part A
سال: 2007
ISSN: 1552-4922,1552-4930
DOI: 10.1002/cyto.a.20422